CAST is a joint government and industry effort that uses a data-driven strategy to reduce the commercial aviation fatality risk in the United States and promote safety initiatives throughout the world. Their work, along with new aircraft, regulations and other activities, reduced the fatality risk for commercial aviation in the United States by 83 percent from 1998 to 2008. 

Seven of CAST's 76 safety enhancements have been derived from forward-looking data analysis in ASIAS. Additionally, ASIAS stays connected to CAST's safety enhancements to track the effectiveness of those interventions. The databases used to identify trends include Flight Operations Quality Assurance (FOQA) programs, the Aviation Safety Action Partnership (ASAP), the Air Traffic Safety Action Program (ATSAP), FAA surveillance data, and many others. 

The agreement outlines the procedures, guidelines, and roles and responsibilities for the ASIAS Executive Board to address specific written NTSB requests for ASIAS information. The agreement does not allow any of the parties to use aggregate FOQA, ASAP, ATSAP or other non-publicly available data to measure an individual data contributor's performance or safety. 

The NTSB will initiate written requests for ASIAS information related to aircraft accidents involving U.S. air carriers that occur in the United States and address safety issues that both the NTSB and the ASIAS board determine are significant and non-routine or reoccurring. The NTSB will not publicly disclose ASIAS information it receives via the process unless the ASIAS Executive Board agrees.

The NTSB will share with ASIAS its archived air carrier accident and incident flight data recorder information related to a request. Peggy Gilligan, Associate Administrator for Aviation Safety, FAA and Captain Paul Morell, Vice President, Safety, Security and Environmental Programs, US Airways signed the agreement for the ASIAS Executive Board. David Mayer, Managing Director, signed for the NTSB.