Lepore and Paladino filed and received their instrument flight plan. Their flight plan was filed “as is” and they were to fly an attitude of 37,000 ft and then a decent to 36,000 ft (Hemispheric altitude rule). The cruise altitude was filed as FL370, with a planned change to FL360 at BRS, and to FL380 at the TERES navigational fix, approximately 282 miles north of BRS. At about 2:51 pm the Embraer Legacy 600 jet departed SBSJ with seven onboard. Enroute to Manaus the pilots of Embraer lost communications with air traffic control (ATC). They made numerous attempts to contact ATC but had no luck.  

Unbeknown to the pilots of the Embraer Legacy 600 and the Boeing 737-800 jets they were on a collision course at 37,000. At about 5 PM both aircraft collided. The Embraer Legacy lost part of its left wing and damage to its tail and the Boeing 737-800 broke-up in flight. Flight 1907 crashed in the dense rainforest in the Amazon jungle killing all 154 onboard. Despite sustaining serious damage to its left wing and tail, the Embraer was able to the safely land at Cachimbo Air Base, approximately 100 miles northwest of the collision site with its seven occupants uninjured.

An investigation was conducted by the Brazilian Aeronautical Accident Prevention and Investigation Center (DIPAA), the Brazilian Air Force's Aeronautical Accidents Investigation and Prevention Center (CENIPA), the NTSB, FAA, Boeing and Honeywell (avionics).